Figure 5.

Absence of fragile histidine triad gene product (Fhit) in a triple negative breast cancer. In the top panels strong expression of Fhit and Wwox is illustrated, in contrast to the negative and very low expression of Fhit and Wwox, respectively, in a triple negative tumor (lower panels). This tumor also shows moderate expression of CK5/6, moderate nuclear expression of AP2α and ‐γ, and strong membranous expression of EGFR (×200 for each photo). This figure was adapted from Figure 1 in reference 43; in this reference, Fhit and Wwox, encoded by the two most active chromosome fragile sites, were investigated for expression in specific subtypes of breast cancer and absence of expression of both of these suppressors was significantly associated with the basal‐like/triple negative subtype.