Figure 5.

Decreased susceptibility to urethane‐induced lung tumors in secretory leukocyte peptidase inhibitor (SLPI)‐deficient mice. Wild‐type or SLPI ^−/– mice were injected intraperitoneally with urethane (1 mg/g bodyweight). The animals were killed (a) 20 or (b) 40 weeks later, and the number of macroscopic external pulmonary nodules was counted. Each bar represents the mean of the group: (a) wild‐type, n = 29 mice; SLPI ^−/–, n = 36 mice; (b) wild‐type, n = 28 mice; SLPI ^−/–, n = 19 mice. Asterisks indicate significant differences at the 95% confidence level between wild‐type and SLPI ^−/– mice.