Skip to main content
. 2008 Nov 19;99(12):2395–2401. doi: 10.1111/j.1349-7006.2008.00970.x

Figure 4.

Figure 4

Insulin‐like growth factor (IGF)‐induced endoplasmic reticulum stress is involved in radiosensitivity under hypoxic conditions. (a) Western blotting and (b) Reverse transcription–polymerase chain reaction of AsPC‐1 cells for the indicated gene products. The conditions are shown above each panel. (c) Western blotting of AsPC‐1 cells, transfected with control vector (Vector) or CHOP expression vector (CHOP). (d) Plating efficiency of the cells in (c,e). Surviving fraction of the cells under hypoxic conditions, transfected with control vector (closed circle) or with CHOP expression vector (open circle). The cells were treated with IGF‐II at 100 ng/mL. Experiments were repeated three times, and the mean ± SD are shown. *P < 0.05, versus control. LY, LY294002; Rap, rapamycin.