Figure 3.
Effects on growth and weight of the FU‐MMT‐3 xenografts. (a) Each curve represents the mean ± SD of the tumor volume (cm3) in each group. Treatment with microspheres alone significantly inhibited the growth of the FU‐MMT‐3 xenografts compared to control. Moreover, a significantly enhanced effect on tumor growth suppression was obtained with treatment of TNP‐470‐loaded microspheres, compared to treatments with 1000 μg/mL TNP‐470 alone and microsphere alone. (b) The mean tumor weight in the FU‐MMT‐3 xenografts resected after treatments. The mean tumor weight after treatment with TCP microspheres or TCP + 1000 μg/mL TNP‐470 was significantly smaller compared to control. The mean tumor weight after treatment of TCP + 1000 μg/mL TNP‐470 was significantly smaller compared to treatment with 1000 μg/mL TCP alone.