. 2008 Jan 2;99(3):451–458. doi: 10.1111/j.1349-7006.2007.00671.x

Table 1.

Phenotype of mismatch repair‐deficient mice

Targeted gene	Increase in mutation frequency ^†	Cancer susceptibility	Sites of cancer	Reference no.
Msh2	7–160	Cancer prone	lymphoma	⁽ 14, 15, 16 ⁾
			GI tract
			Skin
Msh3	2	Low ^‡	GI tract	⁽ ²¹ ⁾
Msh6	2–13	Cancer prone	Lymphoma	⁽ ¹⁹ ⁾
Msh6			GI tract
Mlh1	7–100	Cancer prone	GI tract	⁽ 20, 22 ⁾
Mlh1			Lymphoma
Mlh3	–	Cancer prone	GI tract	⁽ ¹⁷ ⁾
Mlh3			Lymphoma
Pms1	–	No		⁽ ²⁰ ⁾
Pms2	5–100	Cancer prone	Lymphoma	⁽ ²⁰ ⁾
Pms2			Sarcoma

^{^†}

Data of mutation frequencies were obtained from published studies.⁽ ⁹ , ¹⁰ , ¹¹ ⁾

^{^‡}

Overall tumor incidence is not different from wild type, but these mice developed gastrointestinal tract cancer.⁽ ²¹ ⁾GI, gastrointestinal.