Table 3.
Multivariate analysis of overall survival of HNSCC patients with different clinicopathological parameters
| Variable | Overall survival | |||
|---|---|---|---|---|
| P‐value | Hazard ratio | 95% CI for HR | ||
| hMLH1 alteration | 0.014 | 3.98 | 1.31 | 12.12 |
| RBSP3 alteration | 0.022 | 4.43 | 1.23 | 15.88 |
| ITGA9 alteration | 0.319 | 0.552 | 0.172 | 1.77 |
| Tobacco habit | 0.008 | 7.39 | 1.65 | 33.08 |
| HPV infection | 0.013 | 0.229 | 0.071 | 0.737 |
| Nodal invasion | 0.048 | 5.07 | 1.01 | 25.53 |
| Tumor stage | 0.845 | 0.928 | 0.441 | 1.95 |
| Tumor grade | 0.129 | 0.573 | 0.279 | 1.17 |
| Age of patients | 0.705 | 0.774 | 0.207 | 2.92 |
CI, confidence interval; hMLH1, human mismatch repair protein homologue 1; HNSCC, head and neck squamous cell carcinoma; HPV, human papilloma virus; HR, hazard ratio; ITGA9, integrin α RLC; RBSP3, RB1 serine phosphates from human chromosome 3.