Table 1.
Comparison between preoperative and postoperative (total gastrectomy) pharmacokinetic parameters in the plasma of six patients receiving 40 mg/m2 S‐1 orally
| Parameter | Time of test | Tegafur | 5‐Fluorouracil | CDHP | OXO | FUH2 | FBAL |
|---|---|---|---|---|---|---|---|
| T1/2 (h) | Preoperative | 8.7 ± 4.2 | 2.2 ± 0.4 | 2.6 ± 0.6 | 2.8 ± 1.7 | NC | NC |
| Postoperative | 8.1 ± 1.8 | 2.3 ± 0.3 | 3.0 ± 0.6 | 3.5 ± 1.7 | NC | NC | |
| Cmax (ng/mL) | Preoperative | 2520 ± 794 | 125 ± 57 | 282 ± 69 | 55 ± 20 | 148 ± 77 | 62 ± 20 |
| Postoperative | 2715 ± 332 | 166 ± 77** | 453 ± 224 | 210 ± 184* | 156 ± 62 | 72 ± 23 | |
| Tmax (h) | Preoperative | 2.5 ± 1.2 | 4.0 ± 0.0 | 3.0 ± 1.1 | 3.0 ± 1.1 | 7.3 ± 2.1 | 8.7 ± 2.1 |
| Postoperative | 1.2 ± 0.4 | 3.3 ± 1.0 | 1.8 ± 0.4 | 3.0 ± 1.1 | 6.0 ± 0.0 | 8.0 ± 2.2 | |
| AUC1–10h (ng·h/mL) | Preoperative | 16 726 ± 3844 | 680 ± 298 | 1389 ± 398 | 276 ± 113 | 1055 ± 553 | 405 ± 156 |
| Postoperative | 17 726 ± 3368 | 1030 ± 501** | 2163 ± 933** | 1004 ± 904* | 1153 ± 454 | 546 ± 184* |
*
P < 0.05 and
**
P < 0.01 compared to preoperative values tested using the paired Student's t‐test. AUC1–10h, the area under the curve until 10 h after S‐1 administration; CDHP, 5‐chloro‐2,4‐dihydroxypyridine; Cmax, the maximum concentration; FBAL, α‐fluoro‐β‐alanine; FUH2, dihydrofluorouracil; NC, not calculated; OXO, potassium oxonate; T1/2, the half‐life; Tmax, the time required to reach Cmax.