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Products of the Erc/mesothelin gene and the enzyme‐linked immunosorbent assay (ELISA) system. The primary product of the Erc/mesothelin gene, a 71‐kDa precursor protein. This protein is physiologically cleaved, releasing its 31‐kDa N‐terminal fragment into the blood. The authors’ system detects 31‐kDa N‐terminal fragments using a sandwich ELISA containing two antibodies against N‐terminal fragments.
