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A carcinoma invading a capsule at week 10 in a rat treated with sulfadimethoxine following N‐bis(2‐hydroxypropyl)nitrosamine‐initiation. (a) H&E. Original magnification ×180. (b) A serial section of (a). Inducible nitric oxide synthase immunohistochemistry. Some carcinoma cells are weakly positive. (c) A serial section of (a). Single‐strand DNA (ssDNA) immunohistochemistry. Note the diffuse nuclear positivity for ssDNA in carcinoma cells.
