Table 1.
Initial and final bodyweight and thyroid weight of rats treated with sulfadimethoxine (SDM) with or without concomitant administration of aminoguanidine (AG) after N‐bis(2‐hydroxypropyl)nitrosamine (DHPN) initiation
| Group 1 DHPN–SDM + AG | Group 2 DHPN–SDM | Group 3 DHPN–AG | Group 4 DHPN alone | |
|---|---|---|---|---|
| Week 4 | ||||
| No. animals | 10 | 10 | 5 | 5 |
| Initial bodyweight (g) | 127.4 ± 6.2 | 127.2 ± 7.3 | 127.6 ± 6.7 | 127.9 ± 7.0 |
| Final bodyweight (g) | 182.9 ± 6.6*** | 185.8 ± 7.6*** | 210.4 ± 7.9 | 214.2 ± 9.3 |
| Thyroid weight | ||||
| Absolute (mg) | 90.1 ± 12.8*** | 99.1 ± 11.4*** | 11.4 ± 2.5 | 11.4 ± 2.2 |
| Relative (mg/100 g bodyweight) | 49.3 ± 7.4*** | 52.5 ± 5.1*** | 5.5 ± 1.4 | 5.3 ± 1.0 |
| Week 10 | ||||
| No. animals | 14 | 14 | 5 | 5 |
| Initial bodyweight (g) | 127.2 ± 7.2 | 127.6 ± 6.9 | 127.3 ± 6.3 | 127.5 ± 6.6 |
| Final bodyweight (g) | 239.9 ± 10.1*** | 243.5 ± 10.1** | 260.3 ± 5.9 | 263.4 ± 13.8 |
| Thyroid weight | ||||
| Absolute (mg) | 151.4 ± 10.4***, †† | 173.5 ± 20.5*** | 12.2 ± 2.8 | 11.3 ± 1.4 |
| Relative (mg/100 g bodyweight) | 63.1 ± 3.6***, †† | 71.2 ± 7.3*** | 4.7 ± 1.1 | 4.3 ± 0.5 |
Data are mean ± SD values.
**
P < 0.01,
***
P < 0.001 vs group 4 (control);
††
P < 0.01 vs group 2.