Figure 5.

Differential regulation of CD53 gene expression depending on tumor cell type. The transcription factor requirement for human CD53 expression was studied in three lymphoid tumor cell lines of different origin, Namalwa (B‐cell tumor, Burkitt lymphoma), K562 (erythroleukemia) and Molt‐4 (T‐cell lymphoma). The positive or negative effect of transcription factors analyzed by mutagenesis of the CD53 gene promoter^{( 144 )} is indicated by a color‐coded summary of the results. Green (activation), red (inhibition), yellow (no effect).