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. 2009 Sep 14;101(1):129–136. doi: 10.1111/j.1349-7006.2009.01367.x

Figure 6.

Figure 6

 Dimethyloxaloylglycine (DMOG) treatment induces hypoxia‐inducible factor‐1α (HIF‐1α)‐mediated MDR1 expression and MDR1 drug efflux activity. Mouse embryonic fibroblast (MEF) HIF‐1α+/+, MEF HIF‐1α−/−, and HeLa cells were incubated in the presence of 1 mm DMOG for 24 h. Subsequently, MDR1, mS12, or L28 RNA levels, as well as MDR1 protein levels, were determined by RT‐PCR (A) and immunoblots (B). (C) MEF HIF‐1α+/+, MEF HIF‐1α−/−, and (D) HeLa cells were incubated in the presence of 1 mm DMOG for 24 h and MDR1 efflux activity was analyzed. (n = 3 ± SD) *P < 0.05; **P < 0.01.