Table 1.
Candidate peptides derived from IGSF11 and their predicted binding affinities to HLA‐A*0201
| Position † | Sequence (9‐mer) | Score ‡ | Position † | Sequence (10‐mer) | Score ‡ |
|---|---|---|---|---|---|
| 176 | YLWEKLDNT | 1314.6 | 176 | YLWEKLDNTL | 3344.0 |
| 11 | LLLLSLHGV | 1006.2 | 52 | LINLNVIWMV | 280.4 |
| 53 | INLNVIWMV | 49.2 (N.S.) § | 207 | ALSSGLYQCV | 104.3 |
| 59 | WMVTPLSNA | 37.9 | 51 | ALININVIWM | 62.8 (N.S.) § |
| 120 | CLVNNLPDI | 23.9 | 162 | ILLCSSEEGI | 32.1 |
| 15 | SLHGVAASL | 21.3 | 41 | VLPCTFTTSA | 32.0 |
| 252 | VIIIFCIAL | 18.9 (N.S.) § | 12 | LLLSIHGVAA | 31.2 |
| 52 | LINLNVIWM | 14.6 (N.S.) § | 356 | SIYANGTHLV | 30.6 |
| 40 | AVLPCTFTT | 13.9 | 111 | QLSDTGTYQC | 20.3 |
| 207 | ALSSGLYQC | 11.4 | 211 | GLYQCVASNA | 15.8 |
| 384 | VMSRSNGSV | 11.1 | 10 | PLLLISLHGV | 13.0 |
| 104 | SIFINNTQL | 10.8 | 32 | IQVARGQPAV | 11.9 |
| 327 | KVHRNTDSV | 10.4 | 106 | FINNTQLSDT | 10.8 |
| 413 | RIGAVPVMV | 9.5 | 364 | LVPGQHKTLV | 10.3 |
| 132 | NIGVTGLTV | 9.5 | 124 | NLPDIGGRNI | 8.5 |
| 356 | SIYANGTHL | 9.3 | 140 | VLVPPSAPHC | 8.4 |
| 163 | LLCSSEEGI | 8.6 (N.S.) § | 251 | AVIIIFCIAL | 7.1 |
| 13 | LLSLHGVAA | 8.4 | 252 | VIIIFCIALI | 5.6 (N.S.) § |
| 254 | IIFCIALIL | 7.5 | 261 | ILGAFFYWRS | 5.4 |
| 97 | TMPATNVSI | 7.5 | 137 | GLTVIVPPSA | 4.9 |
Amino acid sequences of candidate peptides are listed in the order of binding affinities to HLA‐A*0201 molecules. †The amino acid sequence number for position 1 in the candidate peptide, counting from the N‐terminus of IGSF11. ‡The estimated binding affinity of each peptide to HLA‐A*0201 molecules using Bioinformatics and Molecular Analysis Section software. §Not synthesized due to the hydrophobicity of amino acid sequences.