Figure 1.

 Tissue localizations of the DIX Domain Containing 1 (DIXDC1) and β‐catenin proteins in human colorectal adenocarcinoma tissues. Serial sections of formalin‐fixed and paraffin‐embedded human colon cancer tissue were immunostained with antibodies against β‐catenin (a,c,e) (×100) and DIXDC1 (b,d,f) (×100). Normal colon epithelial cells displayed weak membrane staining of β‐catenin, while colon cancer cells displayed strong cytoplasm/nuclear staining, suggesting the activation of the canonical Wnt pathway. Positive DIXDC1 protein expression was exhibited as diffuse or focal cytoplasmic staining. A significant consistence of DIXDC1 expression and β‐catenin overexpression was observed in colon cancer cells. (g) High power view of (a). (h) High power view of (b).