Table 5.
ABCG2 Q141K and V12M genotype frequencies in Asian healthy subjects and cancer patients from the literature and the present study †
| Polymorphism | No. cases | Race | Disease status | Genotype frequency | Allele frequency | P‐value | Reference | |||
|---|---|---|---|---|---|---|---|---|---|---|
| W/W | W/M | M/M | W | M | ||||||
| c. 421C>A (Q141K) | 145 | Korea | Diffuse large B‐cell lymphoma | 67 (46.2%) | 69 (47.6%) | 9 (6.2%) | 0.700 | 0.300 | This study | |
| 275 | Korea | Healthy control | Not described | 0.720 | 0.280 | 0.306 | ( 10 ) | |||
| 376 | Chinese | Healthy control | 181 (48.1%) | 162 (43.1%) | 33 (8.8%) | 0.697 | 0.303 | 0.849 | ( 16 ) | |
| 95 | Chinese | Healthy control | 41 (43.2%) | 43 (45.3%) | 11 (11.6%) | 0.66 | 0.34 | 0.205 | ( 8 ) | |
| 94 | Chinese | Healthy control | 49 (52.1%) | 38 (40.4%) | 7 (7.4%) | 0.72 | 0.28 | 0.588 | ( 19 ) | |
| 97 | Malays | Healthy control | 54 (55.7%) | 33 (34.0%) | 10 (10.3%) | 0.73 | 0.27 | 0.278 | ( 19 ) | |
| 45 | Chinese | Cancer such as lung, colon, and genitourinary tract | 22 (48.9%) | 23 (51.1%) | 0 (0%) | 0.74 | 0.26 | 0.358 | ( 19 ) | |
| Malays | ||||||||||
| Indians | ||||||||||
| 156 | Chinese | Diffuse large B‐cell lymphoma | 60 (38.5%) | 80 (51.3%) | 16 (10.3%) | 0.64 | 0.36 | 0.023 | ( 16 ) | |
| 105 | Korea | Non‐small cell lung cancer | 59 (56.2%) | 42 (40.0%) | 4 (3.8%) | 0.762 | 0.238 | 0.035 | ( 20 ) | |
| c. 34G>A (V12M) | 145 | Korea | Diffuse large B‐cell lymphoma | 71 (49.0%) | 63 (43.4%) | 11 (7.6%) | 0.707 | 0.293 | This study | |
| 275 | Korea | Healthy control | Not described | 0.770 | 0.230 | 0.001 | ( 10 ) | |||
† Based on the reported ABCG2 Q141K and V12M allele frequencies in Asian population, we compared the frequencies of ABCG2 Q141K polymorphisms using χ2‐tests. M, mutant type; W, wild type.