Table 3.
Effects of the P‐glycoprotein inhibitor on sequence binding protein 1‐mediated multidrug resistance
| Cell line | IC50 value (μg/mL) | |
|---|---|---|
| Adriamycin | MTX | |
| MCF7 | 0.43 ± 0.03 | 0.16 ± 0.01 |
| MCF7‐con | 0.39 ± 0.03 | 0.22 ± 0.03 |
| MCF7‐SATB1 | 22.59 ± 3.11 | 1.15 ± 0.25 |
| MCF7‐SATB1 + P‐gp mAb | 9.37 ± 0.87* | 0.98 ± 0.08 |
*P < 0.05 versus control cells. IC50 values were expressed in μg/mL and were evaluated as reported in Materials and Methods. Standard deviations for all of the experiments carried out in triplicate were <5%. MTX, Methotrexate.