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E2F‐targeted genes. The transcriptional activity of E2F‐1 is negatively regulated by the product of the retinoblastoma tumor suppressor gene (pRB) and is indirectly regulated by a specific cyclin, such as the D‐type cyclins and their associated kinases (Cdk4 and Cdk6). Fibroblast growth factor receptor‐1 (FGFR‐1) and FGFR‐2 represent a new class of genes targeted by E2F. Their expressions are increased at the level of transcription by the overexpression of cyclin D1.
