Figure 1.

 Tissue concentrations of estradiol (a) and estrone (b) in benign breast disease (BBD). Data are represented as box and whisker plots. The median value is represented by a horizontal line in each box. The 75th (upper margin) and 25th (lower margin) percentiles of the values are shown. The upper and lower bars indicate the 90th and 10th percentiles, respectively. Statistical analysis was carried out using the Mann–Whitney U‐test. P‐values <0.05 were considered significant, and are indicated in bold. DCIS, ductal carcinoma in situ; normal, breast tissue with no significant pathological abnormalities.