Table 3.

Age–sex adjusted odds ratios (OR) for the combination of ADH2 and ALDH2 polymorphnisms

	n (case/control)	ALDH2
	† OR (95% CI)	Glu/Glu	Glu/Lys	Lys/Lys
Overall
ADH2	His/His	72/238	61/195	5/38
		1.00 (reference)	0.96 (0.65–1.44)	0.45 (0.17–1.19)
	His/Arg	29/103	40/94	6/16
		0.91 (0.56–1.50)	1.39 (0.88–2.21)	1.46 (0.54–3.95)
	Arg/Arg	7/15	19/13	0/3
		1.65 (0.64–4.27)	5.00 (2.32–10.71)	NE
Never and moderate drinker
ADH2	His/His	36/153	44/164	5/38
		1.00 (reference)	1.13 (0.67–1.89)	0.57 (0.21–1.56)
	His/Arg	12/61	19/74	6/16
		0.84 (0.41–1.73)	1.17 (0.62–2.20)	1.78 (0.64–4.92)
	Arg/Arg	2/9	6/10	0/3
		0.92 (0.189–4.55)	2.57 (0.87–7.61)	NE
Heavy drinker
ADH2	His/His	36/85	17/31	0/0
		1.00 (reference)	1.37 (0.66–2.86)	NE
	His/Arg	17/42	21/20	0/0
		1.00 (0.49–2.02)	2.39 (1.13–5.04)	NE
	Arg/Arg	5/6	13/3	0/0
		2.19 (0.60–8.08)	11.33 (2.97–43.3)	NE

^† OR adjusted for age, sex and smoking. CI, confidence interval; NE, not estimated because of no case in this category.