. 2007 May 8;98(7):1087–1091. doi: 10.1111/j.1349-7006.2007.00505.x

Table 4.

Impact of the ADH2 and ALDH2 polymorphisms in combination with drinking

Drinking ^†	ADH2			P‐trend	ALDH2			P‐trend
Drinking ^†	His/His	His/Arg	Arg/Arg	P‐trend	Glu/Glu	Glu/Lys	Lys/Lys	P‐trend
Never	39/163	16/64	1/9	0.942	16/49	31/133	9/54	0.316
Never	1.00 (Reference)	1.22 (0.63–2.35)	0.50 (0.06–4.11)		1.00 (Reference)	0.75 (0.37–1.53)	0.56 (0.22–1.43)
Ever: moderate drinker	46/192	21/87	7/13	0.227	34/174	38/115	2/3	0.037
Ever: moderate drinker	1.08 (0.66–1.77)	1.06 (0.58–1.94)	2.46 (0.89–6.73)		0.66 (0.32–1.36)	1.05 (0.50–2.20)	3.14 (0.45–21.65)
Heavy drinker	53/116	38/62	18/9	0.002	58/133	51/54	0/0	0.003
Heavy drinker	1.98 (1.20–3.30)	1.66 (1.51–4.71)	9.52 (3.89–23.3)		1.41 (0.69–2.89)	3.13 (1.46–6.72)	NE
P‐trend	0.005	0.056	0.008		0.058	<0.001	0.44

^{^†}

Odds ratios (95% confidence intervals) for head and neck cancer stratified by drinking. NE, not estimated because of no case in this category.