Table 1.

Overexpression of ATP synthase α‐subunit (n = 197) and d‐subunit (n = 190) according to clinicopathological features in colorectal cancers

Clinicopathological findings	n	ATP synthase α‐subunit		ATP synthase d‐subunit
		Case no.	P‐value	Case no.	P‐value
Location
Proximal	74	58	NS	55	NS
Distal	177	139		135
Histological grade
Low	221	181	<0.0001	177	<0.0001
High	30	16		13
Lymphatic invasion
Absent	88	66	NS	65	NS
Present	163	131		125
Venous invasion
Absent	155	118	NS	110	0.026
Present	96	79		80
Depth of invasion
pT1 + pT2	39	32	NS	27	NS
pT3 + pT4	212	165		163
Lymph node metastasis
Absent	106	83	NS	74	0.063
Present	145	114		116
Distant metastasis
Absent	188	144	NS	136	0.032
Present	63	53		54
Liver metastasis
Absent	194	146	0.022	141	0.040
Present	57	51		49
Stage
Stage I + II + III	188	144	NS	136	0.032
Stage IV	63	53		54
Recurrence †
Absent	166	127	NS	122	NS
Present	49	39		37

^† Recurrence in 215 cases underwent curative resection. NS, statistically not significant.