Figure 5.
Correlation between enhancer of zeste homolog 2 (EZH2) expression, expression of E‐cadherin, and the localization of β‐catenin in gastric cancer tissues. The expression of these proteins was evaluated by immunohistochemistry using 114 human gastric adenocarcinomas. (a) EZH2 is normally expressed in the neck region, the proliferative zone for gastric mucosa. HE, hematoylin–eosin. (b) High expression of EZH2 correlated with loss of E‐cadherin expression and nuclear and cytoplasmic localization of β‐catenin. (c) No expression of EZH2 correlated with membranous localization of E‐cadherin or β‐catenin. Lymphoblasts served as appropriate positive controls for EZH2. (d) The relationship between EZH2 expression and negative or membranous localization of E‐cadherin expression in 114 gastric cancer tissues (χ2‐test, P < 0.0001). Bar, 100 µm (a–c).