. 2006 Jul 4;97(8):716–723. doi: 10.1111/j.1349-7006.2006.00236.x

Table 2.

Kinetic analysis of the inhibitory effects of coenzyme Q₁ (CoQ₁) on the activities of DNA polymerase γ, as a function of the DNA template‐primer dose and the dNTP substrate concentration

Substrate	CoQ₁ (µM)	K_m (µM)	V_max (pmol/h)	K_i (µM)	Inhibitory mode
DNA template‐primer ^†	0		41.7
	5.0	6.06	13.0	5.0	Competitive
	10		7.69
	15		5.43
dNTP substrate ^‡	0		47.6
	5.0	1.54	20.4	3.3	Competitive
	10		12.8
	15		9.26

^{^†}

Poly(dA)/oligo(dT)₁₂₋₁₈.

^{^‡}

dTTP. The amount of calf polymerase γ in the assay mixture was 0.05 units. K_i, inhibition constant; K_m, Michaelis constant; V_max, maximum velocity.