Figure 5.

Methylene‐blue‐mediated photodynamic therapy (MB‐PDT) delayed tumor growth in mouse melanoma model. Mice with tumor were treated with the following treatments weekly for three weeks: light alone, MB alone, and MB‐PDT. Tumor volume was determined by direct measurement of tumor dimensions, using calipers. Results are presented as the mean tumor volume ± SEM (n = 8). (a) Morphology contrast of tumors from the three treated groups. (b) Tumor growth curve was expressed as the mean tumor diameters and calculated tumor volumes. (c) Survival plot of melanoma‐bearing mice after various treatments. The time of death, or when mice became moribund, was recorded and plotted as percentage of survival.