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. 2009 Nov 18;101(3):686–692. doi: 10.1111/j.1349-7006.2009.01444.x

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© 2009 Japanese Cancer Association

PMC Copyright notice

Chemokines secreted by LNMTca8113‐stimulated lymphatic endothelial cells (LNMLECs) were chemoattractants for tongue cancer cells and stimulated cell migration. (a) LNMLEC conditioned medium (CM) promoted the migration of Tca8113 cells (*P < 0.05). (b) LNMLEC CM‐induced migration was markedly attenuated with the presence of anti‐CXCL1 and CXCL1/2/3 neutralizing antibody. *P < 0.05 versus CXCL1, CXCL1/2/3, CCL2, CCL20. **P > 0.05 versus CXCL5, CXCL6, CCL7. (c) After the CXCR2 of Tca8113 cells was blocked, LNMLEC CM‐induced migration was significantly attenuated (*P < 0.05).