Chemokines secreted by LNMTca8113‐stimulated lymphatic endothelial cells (LNMLECs) were chemoattractants for tongue cancer cells and stimulated cell migration. (a) LNMLEC conditioned medium (CM) promoted the migration of Tca8113 cells (*P < 0.05). (b) LNMLEC CM‐induced migration was markedly attenuated with the presence of anti‐CXCL1 and CXCL1/2/3 neutralizing antibody. *P < 0.05 versus CXCL1, CXCL1/2/3, CCL2, CCL20. **P > 0.05 versus CXCL5, CXCL6, CCL7. (c) After the CXCR2 of Tca8113 cells was blocked, LNMLEC CM‐induced migration was significantly attenuated (*P < 0.05).