Table 3.
Genes that are down‐regulated in LNMLEC
| UniGene ID | Gene symbol | Gene function | Cytoband | SLR |
|---|---|---|---|---|
| Hs.34341 | CD58 | Cell–cell adhesion | chr1p13 | 1.6 |
| Hs.473417 | CXADR | Cell adhesion | chr21q21.1 | 1.2 |
| Hs.591210 | ITGBL1 | Cell adhesion | chr13q33 | 1.4 |
| Hs.293917 | PVRL3 | Cell adhesion | chr3q13 | 1.1 |
| Hs.590881 | JAG1 | Angiogenesis | chr20p12.1 | 1.2 |
| Hs.485572 | SOCS2 | Anti‐apoptosis | chr12q | 1.3 |
| Hs.170009 | TGFA | Regulation of progression | chr2p13 | 1.1 |
| Hs.189825 | KIAA1244 | Regulation of signal transduction | chr6q23.3 | 1.3 |
| Hs.148670 | RHOBTB1 | Small GTPase‐mediated signal transduction | chr10q21.2 | 1.1 |
| Hs.470646 | RAPGEF4 | Small GTPase‐mediated signal transduction | chr2q31 | 1 |
| Hs.269775 | MAP3K7IP2 | Positive regulation of NF‐kappa B cascade | chr6q25.1 | 1.9 |
| Hs.444975 | PLAGL1 | Cell cycle | chr6q24 | 1 |
| Hs.79347 | ZNF592 | Transcription | chr15q25.3 | 5.9 |
| Hs.184523 | STK38L | Protein kinase cascade | chr12p11.23 | 1 |
| Hs.174312 | TLR4 | Activation of NF‐kappa B‐inducing kinase | chr9q32 | 1.1 |
| Hs.591873 | IL7 | Negative regulation of apoptosis | chr8q12 | 1 |
| Hs.133397 | ITGA6 | Cell–matrix adhesion | chr2q31.1 | 1.1 |
| Hs.533317 | VIM | Cell motility | chr10p13 | 1.4 |
Gene symbols and descriptions are derived from the NCBI UniGene database. Expression ratios refer to LNMTca8113‐stimulated lymphatic endothelial cells (LNMLECs) versus Tca8113‐stimulated LECs (TLECs). Function is derived from the SOURCE database and published literature. SLR, signal log ratio.