Figure 5.

The combined treatment with radiation and BRCA2 siRNA significantly inhibits tumor growth in vivo. BRCA2 siRNA (5 µg/test) were directly injected into HeLa tumor (~50 mm³ on 18 days after inoculation) implanted in BALB/c nude mice. Tumors were irradiated with 8 Gy at 48 h after the injection of BRCA2 siRNA. Closed arrows: BRCA2 siRNA injection; open arrows: radiation. Open square: control; closed square: 8 Gy gamma‐rays; closed circular: BRCA2 siRNA; open circle: combination of BRCA2 siRNA and 8 Gy gamma‐rays. Data represent the mean and standard deviation of tumor size at each measuring point.