Figure 7.

TZT‐1027 potentiates enhanced vascular permeability induced by vascular endothelial growth factor (VEGF), but not by bradykinin. A single dose of 0.5 mg/kg TZT‐1027 or vehicle (saline) was administered to the guinea pigs intravenously 15 min prior to intradermal injection of saline, bradykinin or VEGF. Immediately after the intradermal injection, 1% Evans blue in saline was administered intravenously at 2 mL/kg. After 30 min, the dorsal skins were extirpated and amounts of Evans blue were measured. Each point represents the mean ± SD of six animals. *P < 0.05, **P < 0.01, significantly different from the vehicle treatment group (Student's t‐test).