Table 1.

Antitumor activity of TZT‐1027 against advanced‐stage Colon26 tumors

Drug	Dose (mg/kg)	MST (days)	ILS (%)	P‐value	Toxic death
Control	–	12.0	–	–	0/8
TZT‐1027	1	16.8	39.6	0.033	0/8
TZT‐1027	2	19.0	58.3	0.0019	0/8
TZT‐1027	4	16.8	108.3	0.0013	1/8

A single dose of 1, 2 or 4 mg/kg TZT‐1027 or vehicle (LB) was administered when the tumor volume reached approximately 400–600 mm³. Antitumor activity was evaluated in terms of the increase in life span (ILS), defined as ([Median survival time {MST} treated]/[MST control] − 1) × 100. Statistical analysis was carried out using the log‐rank test based on the Kaplan–Meier method. A significant difference from the survival of the control group is represented. Toxic death means the number of mice that died/number of mice that were used.