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. 2010 Feb 2;101(4):955–962. doi: 10.1111/j.1349-7006.2009.01485.x

Figure 4.

Figure 4

 Effect of CPT‐11/SN‐38 on cell proliferation. (a) SKOV‐3 cells were treated with CPT‐11 or SN‐38 at a concentration of 1 μg/mL or 100 μg/mL for 24 h. (b) HB1.F3.CE cells were treated with CPT‐11. Proliferation levels at each concentration of CPT‐11 and SN‐38 are expressed as relative fold change. Values are the mean ± SD of two independent experiments. *P < 0.05 compared CPT‐11 controls; **P < 0.05 compared SN‐38 controls. (c) SKOV‐3 cells were seeded in 24 well plates. Following incubation for 24 h, increasing numbers of HB1.F3.CE cells were placed on the membrane of inserts. After 24 h, the cells were treated with CPT‐11 at a concentration of 1 μg/mL for 24 h. Values of (c) are presented as the mean ± SD of three independent experiments. *P < 0.05 compared to controls.