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Antitumor effect of mono‐ or combination chemotherapy in colorectal tumor‐bearing mice. Control (non‐treated, □); S‐1 dosing (daily, ); free l‐OHP (weekly, △); S‐1 dosing (daily) plus free oxaliplatin (l‐OHP) (weekly) (); l‐OHP‐containing polyethylene glycol (PEG)‐coated liposomes (weekly, ○); S‐1 dosing (daily) plus l‐OHP‐containing PEG‐coated liposomes (weekly) (•). Data represent mean ± SD (n = 5). *P < 0.05.
