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Effect of S‐1 dosing on tumor accumulation of oxaliplatin (l‐OHP) delivered by polyethylene glycol (PEG)‐coated liposomes. Oxaliplatin‐containing PEG‐coated liposomes were intravenously administered into tumor‐bearing mice that were pre‐treated with or without S‐1 dosing for 7 days. At various time points, tumor tissue was collected and then l‐OHP in the tissue was determined. Data represent mean ± SD (n = 3). *P < 0.05 vs control.
