Table 3.
Incidence of follicular epithelial cell lesions in thyroid capsules of goitrogen‐treated rats with or without DHPN initiation
| Group | Treatments | Week | No. animals | Migration of follicular epithelial cells in capsules | Pockets of residual follicular tissue in capsules | ||
|---|---|---|---|---|---|---|---|
| Multifocal | Diffuse | Number/rat | |||||
| 1–3 | 3< | ||||||
| 1 | DHPN + PTU | 4 | 10 | 6 (60) † | 1 (10) a | 4 (40) | 0 |
| 10 | 10 | 10 (100) | 0 | 7 (70) | 0 [Link] , [Link] | ||
| 2 | PTU alone | 4 | 10 | 9 (90) | 1 (10) b | 6 (60) | 0 |
| 10 | 10 | 9 (90) | 0 | 6 (60) | 4 (40) c | ||
| 3 | DHPN + SDM | 4 | 9 | 3 (33) | 6 (67) a | 2 (22) | 0 |
| 10 | 10 | 10 (100) | 0 | 4 (40) | 6 (60) d | ||
| 4 | SDM alone | 4 | 10 | 3 (30) | 7 (70) b | 1 (10) | 0 |
| 10 | 10 | 10 (100) | 0 | 2 (20) | 8 (80) | ||
DHPN, N‐bis(2‐hydroxypropyl)nitrosamine; PTU, 6‐propyl‐2‐thiouracil; SDM, sulfadimethoxine; †percentage. Superscript letters indicate significance between values with the same letter: a,b,c P < 0.05; d P < 0.01 (Mann–Whitney's U‐test).