Table 6.
Ki‐67‐positivity in thyroid adenomas with or without COX‐2 expression in goitrogen‐treated rats after DHPN initiation
| Group | Treatments | Week | Adenomas | Adenomas | Surrounding follicles | |||
|---|---|---|---|---|---|---|---|---|
| n | COX‐2 (–) | n | COX‐2 (+/++) | n | COX‐2 (++) | |||
| 1 | DHPN + PTU | 10 | 10 | 9.0 ± 4.3*, † | 10 | 9.1 ± 5.7* | 10 | 1.9 ± 0.3 |
| 3 | DHPN + SDM | 10 | 10 | 10.2 ± 3.1* | 9 | 9.6 ± 3.8* | 10 | 1.9 ± 0.7 |
DHPN, N‐bis(2‐hydroxypropyl)nitrosamine; PTU, 6‐propyl‐2‐thiouracil; SDM, sulfadimethoxine; n, number of lesions; †mean ± SD. *P < 0.01 compared with surrounding follicles (Welch's t‐test).