Table 2.
Protein peaks differentially expressed in PaCa and healthy control serum detected on SAX2 chip including the independent training and testing sets and the AUC for differential diagnosis between PaCa and healthy control
| m/z (Da) | P value | Intensity PaCa (test) | Intensity control (test) | AUC (P < 0.001) |
|---|---|---|---|---|
| 4137 | 2.00E‐09 | 5.93 ± 5.74/5.28 ± 2.44 | 2.19 ± 1.15/2.38 ± 0.79 | 0.856 ± 0.035 |
| 12 441 | 1.40E‐09 | 4.73 ± 4.36/5.96 ± 5.89 | 1.36 ± 1.29/2.74 ± 2.17 | 0.837 ± 0.038 |
| 4359 | 2.56E‐08 | 5.96 ± 4.61/5.51 ± 1.12 | 2.87 ± 1.30/2.61 ± 1.21 | 0.810 ± 0.041 |
| 4791 | 3.89E‐08 | 3.86 ± 3.70/3.72 ± 1.55 | 1.83 ± 0.65/2.00 ± 0.68 | 0.806 ± 0.042 |
| 28 068 | 1.76E‐07 | 2.45 ± 2.73/3.40 ± 4.12 | 0.61 ± 0.61/1.11 ± 0.98 | 0.791 ± 0.042 |
| 4016 | 2.44E‐07 | 2.16 ± 1.61/2.38 ± 1.42 | 0.86 ± 0.65/0.74 ± 0.61 | 0.787 ± 0.043 |
| 12 600 | 2.04E‐06 | 2.84 ± 1.97/3.60 ± 3.50 | 1.46 ± 1.22/2.68 ± 2.05 | 0.764 ± 0.046 |
| 4541 | 2.60E‐06 | 4.45 ± 3.59/4.23 ± 2.50 | 2.16 ± 1.47/2.00 ± 1.61 | 0.762 ± 0.046 |
| 15 123 | 2.92E‐06 | 1.54 ± 2.01/1.47 ± 0.72 | 2.62 ± 1.60/3.35 ± 2.45 | 0.760 ± 0.046 |
| 8777 | 3.01E‐06 | 3.34 ± 1.70/3.79 ± 1.92 | 5.06 ± 1.53/4.87 ± 0.98 | 0.760 ± 0.045 |
| 15 885 | 1.37E‐05 | 0.49 ± 0.80/0.47 ± 0.26 | 0.94 ± 0.77/1.28 ± 1.04 | 0.742 ± 0.047 |
| 8685 | 3.93E‐05 | 4.85 ± 2.77/5.75 ± 2.92 | 6.95 ± 1.64/6.91 ± 1.71 | 0.729 ± 0.048 |
| 4124 | 4.48E‐05 | 3.27 ± 2.75/4.83 ± 2.98 | 1.66 ± 1.24/1.60 ± 1.00 | 0.727 ± 0.049 |
| 17 250 | 4.48E‐05 | 1.13 ± 0.83/1.03 ± 0.78 | 1.75 ± 0.63/1.77 ± 0.38 | 0.727 ± 0.049 |
| 4629 | 4.60E‐05 | 14.09 ± 11.31/12.41 ± 5.07 | 7.62 ± 5.22/8.52 ± 5.06 | 0.727 ± 0.048 |
| 3444 | 4.98E‐05 | 1.84 ± 2.29/2.05 ± 1.92 | 0.62 ± 0.66/0.57 ± 0.48 | 0.726 ± 0.048 |
| 6889 | 8.31E‐05 | 3.50 ± 1.25/3.31 ± 0.95 | 4.56 ± 1.35/4.05 ± 1.38 | 0.719 ± 0.049 |
| 28 083 | 1.02E‐04 | 1.68 ± 1.97/1.45 ± 1.64 | 2.68 ± 2.00/2.11 ± 2.13 | 0.716 ± 0.050 |
| 5071 | 1.59E‐04 | 2.43 ± 1.93/1.95 ± 1.18 | 1.30 ± 0.55/1.43 ± 0.68 | 0.710 ± 0.049 |
| 8812 | 2.28E‐04 | 4.34 ± 2.86/5.63 ± 3.53 | 6.06 ± 2.32/7.38 ± 1.96 | 0.705 ± 0.050 |
| 13 864 | 2.95E‐04 | 15.08 ± 7.85/18.90 ± 7.95 | 20.38 ± 5.98/19.98 ± 7.60 | 0.701 ± 0.050 |
| 4056 | 4.09E‐04 | 2.45 ± 2.73/2.32 ± 0.78 | 1.23 ± 1.62/0.92 ± 0.58 | 0.697 ± 0.051 |
| 4190 | 5.25E‐04 | 5.80 ± 5.63/2.31 ± 0.69 | 3.76 ± 4.75/3.59 ± 3.72 | 0.693 ± 0.052 |
| 14 040 | 5.62E‐04 | 6.07 ± 2.97/7.58 ± 2.46 | 8.12 ± 2.00/7.73 ± 2.55 | 0.692 ± 0.050 |
| 8561 | 7.18E‐04 | 1.74 ± 1.48/1.15 ± 0.68 | 2.54 ± 1.07/1.85 ± 0.70 | 0.688 ± 0.051 |
| 7562 | 8.56E‐04 | 1.05 ± 1.59/1.04 ± 0.73 | 1.83 ± 1.63/2.43 ± 2.46 | 0.686 ± 0.052 |