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. 2009 Oct 10;101(2):550–558. doi: 10.1111/j.1349-7006.2009.01390.x

Figure 6.

Figure 6

 Involvement of 15‐hydroxyprostaglandin dehydrogenase (15‐PGDH) in proliferation in gastric adenocarcinoma cells. (a) Effects of prostaglandin (PG) E2 on proliferation of AGS cells. (b) Effects of 16, 16‐dimethyl PGE2 on proliferation of AGS cells. Cell proliferation was estimated by WST‐1 cell proliferation assay. (c) Effect of 15‐PGDH inhibitor (CAY 10397) on proliferation of AGS cells. Cell proliferation was estimated by WST‐1 cell proliferation assay. (d) Effect of 15‐PGDH inhibitor (CAY 10397) on proliferation of AGS cells. Cell proliferation was estimated by BrdU staining. (e) AGS cells were subjected to Western blotting and real‐time RT‐PCR 24 h after transfection with 15‐PGDH‐specific siRNA. (f) Effect of transfection with 15‐PGDH‐specific siRNA on proliferation of AGS cells. (g) Effect of transfection with 15‐PGDH‐specific siRNA on proliferation of MKN7 cells. Cell proliferation was estimated by WST‐1 cell proliferation assay. Values are the mean ± SD.