Skip to main content

View full-text article in PMC

. 2007 May 22;98(8):1248–1253. doi: 10.1111/j.1349-7006.2007.00519.x

Table 3.

Combined effects of ADH2 or ADH3 polymorphism with the ALDH2 polymorphism on the risk of colorectal cancer in alcohol drinkers

ADH2/ADH3		ALDH2 Glu487Lys
ADH2/ADH3		Glu/Glu	Glu/Lys
ADH2 Arg47His
His/His	No. ^†	153/170	50/84
His/His	OR (95% CI) ^‡	1.00 (referent)	0.70 (0.46–1.07)
Arg/His + Arg/Arg	No.	148/143	57/62
Arg/His + Arg/Arg	OR (95% CI)	1.12 (0.81–1.55) Interaction P = 0.30	1.08 (0.70–1.67)
ADH3 Ile349Val
Ile/Ile	No.	274/283	100/135
Ile/Ile	OR (95% CI)	1.00 (referent)	0.83 (0.60–1.14)
Ile/Val + Val/Val	No.	28/30	10/11
Ile/Val + Val/Val	OR (95% CI)	1.00 (0.58–1.74) Interaction P = 0.76	0.98 (0.40–2.38)

^{^†}

Numbers of cases/controls.

^{^‡}

^‡ Adjusted for sex, 5‐year age class, area, and alcohol use low or high intake. CI, confidence interval; OR, odds ratio.