Figure 6.
Inhibiting regulatory T cell recovery by treatment with anti‐transforming growth factor (TGF)‐β mAb leads to complete rejection of carcinoma. CMC‐1 (2 × 105) cells were inoculated at day 0 into BALB/c mice pre‐treated with control IgG of PC61 (open circle, open triangle) or anti‐CD25 mAb (PC61; filled circle, filled triangle). Anti‐TGF‐β mAb (1D11; open triangle, filled circle) or control IgG of 1D11 (open circle, filled triangle) was injected i.p. six times at 2‐day intervals. Effects of the anti‐CD25 mAb and anti‐TGF‐β treatment were evaluated by monitoring subsequent tumor growth. The data shown are the mean ± SD of four mice. Photographs are representative at day 14. Similar results were obtained in three separate experiments.