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. 2010 Jun 9;101(9):2011–2018. doi: 10.1111/j.1349-7006.2010.01640.x

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© 2010 Japanese Cancer Association

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Enhancement of integrin αvβ5‐dependent migration of LS‐LM6 by hepatocyte‐conditioned medium (HCM). (a) Migration of LS‐LM6 on vitronectin (VN) by HCM. Both LS174T and LS‐LM6 can migrate 100–300 cells on VN without stimulation. The migration of LS‐LM6 is enhanced up to sixfold by HCM (×1) and 6.9‐fold by the twice‐concentrated HCM (×2) compared with the control medium (*P < 0.05, two‐way anova). LS174T shows no significant migration by HCM. The filtrated fraction containing the low‐molecular weight proteins (FCM) has no effect on cell migration. (b) The enhanced migration of LS‐LM6 on VN by HCM is significantly inhibited by the neutralizing antibodies against integrins αvβ5 and αv, and VN (*P < 0.05, two‐way anova).