Table 1.

Relationship between single nucleotide polymorphisms (SNPs) in candidate genes and leukopenia/neutropenia risk induced by docetaxel

Gene	SNP ID	ADR, N = 28				Non‐ADR, N = 56				P‐value			Odds ratio (95% CI)
		11 †	12	22	MAF	11 †	12	22	MAF	1 versus 2	versus 11	versus 22	versus 11	versus 22
CYP3A4	rs2740574	27	0	0	0.00	56	0	0	0.00	NA	NA	NA	NA	NA
	CYP3A4*4	27	0	0	0.00	55	0	0	0.00	NA	NA	NA	NA	NA
	rs12721627	28	0	0	0.00	53	1	0	0.01	1.0	1.0	1.0	NA	NA
	rs28371759	26	1	0	0.02	54	1	0	0.01	1.0	1.0	1.0	2.08 [0.12–34.53]	NA
CYP3A5	rs776746	19	7	1	0.17	28	26	2	0.27	0.18	0.10	1.0	2.38 [0.89–6.32]	1.04 [0.09–11.98]
ABCB1	rs2157929	20	6	2	0.18	43	12	0	0.11	0.23	0.59	0.11	1.43 [0.50–4.06]	NA
	rs1978095	10	16	2	0.36	33	17	6	0.26	0.21	0.064	0.71	2.58 [1.01–6.60]	1.56 [0.29–8.28]
	rs13233308	11	11	5	0.39	19	23	14	0.46	0.50	0.63	0.59	1.34 [0.51–3.45]	1.47 [0.46–4.60]
	rs2188524	20	7	0	0.13	51	3	1	0.05	0.062	0.035*	1.0	4.46 [1.18–16.92]	NA
	rs3789243	7	18	2	0.41	24	19	13	0.40	1.0	0.15	0.13	2.14 [0.78–5.89]	3.78 [0.78–18.13]
	rs1202172	21	6	0	0.11	50	6	0	0.05	0.21	0.19	1.0	2.38 [0.68–8.24]	NA
	rs10256836	19	7	1	0.17	41	12	3	0.16	1.0	0.80	1.0	1.15 [0.41–3.18]	1.47 [0.14–14.85]
	rs868755	13	12	3	0.32	20	23	13	0.44	0.18	0.48	0.24	1.56 [0.61–3.92]	2.52 [0.65–9.71]
	rs1922242	14	9	4	0.31	23	27	5	0.34	0.86	0.48	0.47	1.50 [0.59–3.78]	1.74 [0.42–7.08]
	rs3789246	19	6	2	0.19	41	15	0	0.13	0.49	0.80	0.10	1.15 [0.41–3.18]	NA
	rs7787082	5	17	5	0.50	21	28	6	0.36	0.13	0.083	0.49	2.72 [0.87–8.27]	1.86 [0.51–6.74]
	rs2373588	8	14	6	0.46	26	23	7	0.33	0.13	0.16	0.34	2.17 [0.81–5.74]	1.91 [0.57–6.34]
	rs6949448	14	11	3	0.30	18	22	14	0.46	0.065	0.16	0.15	2.00 [0.78–5.08]	2.92 [0.76–11.18]
	rs1002205	8	15	5	0.45	22	28	6	0.36	0.31	0.47	0.49	1.62 [0.60–4.31]	1.81 [0.50–6.55]
	rs1882478	9	17	2	0.38	16	27	13	0.47	0.25	0.80	0.13	1.18 [0.44–3.16]	3.93 [0.82–18.82]
	rs2235046	12	10	6	0.39	20	30	6	0.38	0.87	0.64	0.32	1.35 [0.53–3.41]	2.27 [0.65–7.84]
	rs2235067	25	3	0	0.05	51	5	0	0.05	1.0	1.0	1.0	1.22 [0.27–5.54]	NA
	rs1045642	12	13	2	0.31	18	25	12	0.45	0.13	0.34	0.13	1.64 [0.63–4.23]	3.49 [0.72–16.87]
	rs1128503	12	11	5	0.38	21	29	6	0.37	1.0	0.81	0.49	1.25 [0.49–3.15]	1.81 [0.50–6.55]
	rs3213619	22	5	0	0.09	53	3	0	0.03	0.11	0.11	1.0	4.02 [0.88–18.27]	NA
ABCC2	rs12268782	18	9	1	0.20	45	11	0	0.10	0.091	0.18	0.33	2.27 [0.82–6.28]	NA
	rs2804398	24	4	0	0.07	43	12	0	0.11	0.58	0.56	1.0	1.67 [0.48–5.77]	NA
	rs2756109	12	14	2	0.32	29	23	3	0.26	0.47	0.49	1.0	1.49 [0.59–3.72]	1.33 [0.20–8.48]
	rs11190291	20	7	1	0.16	50	6	0	0.05	0.041*	0.060	0.33	3.33 [1.03–10.83]	NA
	rs2002042	11	13	4	0.38	31	19	6	0.28	0.22	0.25	0.73	1.92 [0.76–4.83]	1.39 [0.35–5.39]
	rs3740065	15	9	4	0.30	14	30	11	0.47	0.046*	0.015*	0.57	3.38 [1.30–8.82]	1.50 [0.43–5.22]
	rs12762549	7	12	9	0.54	28	23	5	0.30	0.0038*	0.036*	0.012*	3.00 [1.10–8.18]	4.83 [1.44–16.26]
	rs2862691	18	10	0	0.18	34	19	3	0.22	0.55	0.82	0.55	1.16 [0.45–2.98]	NA
	rs11598781	18	10	0	0.18	32	22	2	0.23	0.55	0.64	0.55	1.35 [0.52–3.45]	NA
	rs11190303	17	9	2	0.23	15	32	7	0.43	0.016*	0.0047*	0.49	4.02 [1.53–10.54]	1.94 [0.37–10.01]
	rs2273697	20	7	1	0.16	49	7	0	0.06	0.052	0.13	0.33	2.80 [0.89–8.75]	NA
SLCO1B3	rs7311358	17	7	3	0.24	21	29	6	0.37	0.12	0.036*	1.0	2.83 [1.10–7.33]	1.04 [0.23–4.53]
	rs4149118	7	14	7	0.50	20	25	11	0.42	0.41	0.46	0.78	1.67 [0.60–4.60]	1.36 [0.46–4.02]
	rs919840	18	3	0	0.07	35	12	1	0.15	0.27	0.36	1.0	2.23 [0.56–8.84]	NA
	rs3764006	12	15	0	0.28	35	18	2	0.20	0.32	0.15	0.55	2.19 [0.85–5.58]	NA
	rs11045585	15	13	0	0.23	49	7	0	0.06	0.0023*	0.0010*	1.0	6.07 [2.05–17.97]	NA
	rs10841661	18	8	1	0.19	33	15	8	0.28	0.25	0.63	0.26	1.39 [0.53–3.64]	4.33 [0.51–36.57]
	rs3764009	20	4	3	0.19	29	21	5	0.28	0.25	0.093	1.0	2.56 [0.93–7.04]	1.25 [0.27–5.67]
	rs2117032	10	12	5	0.41	21	25	10	0.40	1.0	1.0	1.0	1.02 [0.39–2.64]	1.05 [0.31–3.43]
	rs980084	9	16	2	0.37	21	26	8	0.38	1.0	0.81	0.49	1.24 [0.46–3.25]	2.13 [0.41–10.79]
	rs2417886	28	0	0	0.00	56	0	0	0.00	NA	NA	NA	NA	NA
	rs7977213	17	10	0	0.19	34	14	5	0.23	0.68	1.0	0.16	1.05 [0.40–2.75]	NA
	rs4149154	22	3	2	0.13	34	19	3	0.22	0.21	0.080	1.0	2.85 [0.93–8.63]	1.41 [0.22–9.00]
	rs12228798	19	8	0	0.15	39	15	2	0.17	0.83	1.0	0.56	1.04 [0.37–2.82]	NA
	rs7312051	22	4	0	0.08	41	12	1	0.13	0.43	0.41	1.0	1.74 [0.50–5.99]	NA
	rs10841714	21	7	0	0.13	38	17	1	0.17	0.51	0.62	1.0	1.42 [0.51–3.95]	NA
	rs4424716	23	4	0	0.07	44	10	1	0.11	0.58	0.76	1.0	1.44 [0.41–5.02]	NA
	rs10734711	13	10	3	0.31	31	17	4	0.24	0.44	0.47	0.68	1.48 [0.57–3.81]	1.57 [0.32–7.58]
	rs11045639	7	13	7	0.50	22	27	7	0.37	0.13	0.33	0.21	1.85 [0.67–5.10]	2.45 [0.76–7.89]
	rs2174012	17	10	0	0.19	15	33	7	0.43	0.0028*	0.0034*	0.089	4.53 [1.70–12.09]	NA
	rs2900459	12	11	5	0.38	13	32	11	0.48	0.25	0.079	1.0	2.48 [0.93–6.56]	1.12 [0.34–3.62]
	rs4762693	7	13	7	0.50	20	25	7	0.38	0.17	0.32	0.22	1.79 [0.63–4.98]	2.25 [0.69–7.27]
	rs7975631	22	4	0	0.08	45	10	1	0.11	0.59	0.77	1.0	1.34 [0.38–4.71]	NA
	rs4149117	18	7	3	0.23	21	29	6	0.37	0.11	0.036*	1.0	3.00 [1.17–7.71]	1.00 [0.23–4.34]
NR1I2	rs12488820	15	11	1	0.24	30	23	3	0.26	0.85	1.0	1.0	1.08 [0.43–2.73]	1.47 [0.14–14.85]
	rs4440154	11	11	6	0.41	25	25	5	0.32	0.30	0.65	0.17	1.29 [0.51–3.25]	2.73 [0.75–9.89]
	rs7643645	8	14	5	0.44	21	24	9	0.39	0.61	0.47	1.0	1.51 [0.56–4.07]	1.14 [0.34–3.80]
	rs2461825	11	13	2	0.33	23	26	6	0.35	0.86	1.0	0.72	1.02 [0.39–2.62]	1.47 [0.27–7.83]
	rs2472682	9	16	2	0.37	16	35	4	0.39	0.87	0.80	1.0	1.22 [0.45–3.28]	1.02 [0.17–5.95]
	rs12633127	8	16	3	0.41	31	22	1	0.22	0.017*	0.033*	0.11	3.20 [1.19–8.59]	6.63 [0.65–67.01]
	rs6784598	3	18	7	0.57	12	33	10	0.48	0.33	0.25	0.57	2.33 [0.59–9.04]	1.50 [0.50–4.49]
	rs9815093	14	13	1	0.27	29	24	3	0.27	1.0	1.0	1.0	1.07 [0.43–2.66]	1.53 [0.15–15.40]
	rs13070374	19	9	0	0.16	32	22	2	0.23	0.32	0.48	0.55	1.58 [0.61–4.11]	NA
	rs11712308	15	11	2	0.27	25	24	6	0.33	0.48	0.50	0.71	1.38 [0.55–3.45]	1.59 [0.29–8.45]
	rs2293214	18	10	0	0.18	39	16	1	0.16	0.83	0.81	1.0	1.27 [0.48–3.33]	NA
NR1I3	rs11432	6	13	5	0.48	25	19	11	0.37	0.22	0.13	1.0	2.50 [0.86–7.26]	1.05 [0.32–3.45]
	rs7528588	13	13	2	0.30	34	15	7	0.26	0.58	0.25	0.71	1.78 [0.71–4.46]	1.86 [0.35–9.59]
	rs5085	13	12	2	0.30	33	15	8	0.28	0.86	0.48	0.49	1.55 [0.61–3.89]	2.08 [0.41–10.56]
	rs4233368	9	14	5	0.43	20	26	10	0.41	0.87	0.81	1.0	1.17 [0.44–3.07]	1.00 [0.30–3.27]
	rs2307418	27	1	0	0.02	45	11	0	0.10	0.11	0.094	1.0	6.60 [0.80–54.01]	NA
	rs7417867	9	13	6	0.45	28	21	7	0.31	0.12	0.16	0.34	2.11 [0.81–5.46]	1.91 [0.57–6.34]
	rs11584174	15	11	1	0.24	24	24	7	0.35	0.21	0.35	0.26	1.61 [0.63–4.08]	3.79 [0.44–32.52]
	rs2501870	16	9	2	0.24	28	20	7	0.31	0.46	0.49	0.71	1.40 [0.55–3.56]	1.82 [0.35–9.44]
	rs11265572	24	3	0	0.06	44	11	0	0.10	0.39	0.37	1.0	2.00 [0.50–7.87]	NA

^† Major allele in non‐ADRs was defined as allele 1.

^* P < 0.05.

ADR, adverse drug reaction; CI, confidence interval; NA, not available.