Skip to main content
. 2010 Jul 7;101(10):2269–2277. doi: 10.1111/j.1349-7006.2010.01674.x

Figure 6.

Figure 6

 Staining pattern of C4.4A and prognosis of patients with colorectal cancer. Kaplan–Meier 5‐year overall survival (OS) curves for patients with stage I–IV tumors (n = 132). The cases were categorized as: (A) translocation from cytoplasm to membrane and with enhanced intensity (n = 34); (B1) translocation but without enhanced intensity (n = 12); (B2) no translocation but with enhanced intensity (n = 15); or (C) no translocation and without enhanced intensity (n = 71). Change of localization from cytoplasm to the plasma membrane (A + B1) or increase in intensity (A + B2) at the invasive front was associated with shorter 5‐year OS (P = 0.023 and P = 0.0031, respectively). More striking differences were noted between Type A and other expression and localization types (B1 + B2 + C) (P = 0.0013). (B) The 5‐year disease‐free survival in patients with stage II and III tumors (n = 82). When these patients were analyzed for 5‐year disease‐free survival after curative surgery, similar results to those in 5‐year OS were obtained (P = 0.011, P = 0.0016, and P = 0.0004, respectively).