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. 2010 Jul 7;101(10):2269–2277. doi: 10.1111/j.1349-7006.2010.01674.x

Figure 8.

Figure 8

  In vitro cultures of HCT116 colon cancer cells. (A) The C4.4A protein expression was observed in the nucleus of HCT116 in 2D culture. (B) The 3D cell cultures in collagen gels. The HCT116 cells on the gels expressed C4.4A protein in the cytoplasm, whereas the protein was often localized to the plasma membrane when the cells were surrounded by a collagen matrix. Note that the collagen matrix tended to become degraded when the cells had membranous C4.4A expression. The arrows indicate intense membranous staining. Magnification, ×200.