Table 4.
Overall survival analysis in colorectal cancer patients with stage I–IV tumors (n = 132)
| Univariate analysis | P‐value |
|---|---|
| Sex (male vs female) | NS |
| Age (≥62 years vs <62 years) | NS |
| Tumor size (≥4.5 cm vs <4.5 cm) median | 0.004 |
| Differentiation (well,mod vs por,muc) | NS |
| Depth of invasion (∼mp vs ss∼) | NS |
| Lymph node metastasis (positive vs negative) | <0.001 |
| Venous invasion (positive vs negative) | NS |
| Distant metastasis (positive vs negative) | <0.001 |
| Liver metastasis (positive vs negative) | 0.002 |
| Lung metastasis (positive vs negative) | 0.048 |
| Peritoneal dissemination (positive vs pegative) | 0.007 |
| Expression of C4.4A (A vs B and C) | 0.001 |
| Multivariate analysis | Risk ratio | Confidence interval | P‐value |
|---|---|---|---|
| Expression of C4.4A (A vs B and C) | 3.536 | 1.497–8.354 | 0.004 |
| Tumor size (≥4.5 cm vs <4.5 cm) | 3.155 | 1.134–8.780 | 0.028 |
| Lymph node metastasis (positive vs negative) | 6.218 | 1.998–19.352 | 0.002 |
| Distant metastasis (positive vs negative) | 1.771 | 0.739–4.247 | NS |
| Peritoneal dissemination (positive vs negative) | 5.689 | 1.641–19.717 | 0.004 |
Colorectal cancer cases were categorized as: (A) translocation from cytoplasm to membrane and with enhanced intensity; (B1) translocation but without enhanced intensity; (B2) no translocation but with enhanced intensity; or (C) no translocation and without enhanced intensity. mp, muscularis propria; NS, not significant; por,muc, poorly differentiated adenocarcinoma or mucinous carcinoma; ss, subserosa; well,mod, well or moderately differentiated adenocarcinoma.