Table 5.

 Disease‐free survival analysis in colorectal cancer patients with stage II and III tumors (n = 82)

Univariate analysis	P‐value
Sex (male vs female)	NS
Age (≥62 years vs <62 years)	NS
Tumor size (≥5.0 cm vs <5.0 cm)	NS
Differentiation (well,mod vs por,muc)	NS
Depth of invasion (∼mp vs ss∼)	NS
Tumor site (colon vs rectum)	NS
Lymph node metastasis (positive vs negative)	0.017
Venous invasion (positive vs negative)	NS
Expression of C4.4A (A vs B and C)	<0.001

Multivariate analysis	Risk ratio	Confidence interval	P‐value
Expression of C4.4A (A vs B and C)	4.261	1.664–10.907	0.003
Lymph node metastasis (positive vs negative)	2.732	1.033–7.426	0.043

Colorectal cancer cases were categorized as: (A) translocation from cytoplasm to membrane and with enhanced intensity; (B1) translocation but without enhanced intensity; (B2) no translocation but with enhanced intensity; or (C) no translocation and without enhanced intensity. mp, muscularis propria; NS, not significant; por,muc, poorly differentiated adenocarcinoma or mucinous carcinoma; ss, subserosa; well,mod, well or moderately differentiated adenocarcinoma.