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. 2010 Apr 28;101(8):1813–1821. doi: 10.1111/j.1349-7006.2010.01605.x

Figure 6.

Figure 6

 Cross‐resistance pattern of triple‐mutant breast cancer resistance protein (BCRP) transfectants. The cells were incubated for 4 days at 37°C in the presence or absence of various concentrations of mitoxantrone, topotecan, or doxorubicin. Cell numbers were determined with a Coulter counter. Data are the mean ± SD of triplicate determinations. PA317 and PA/WT‐mix were used as control cell lines. (a) Mitoxantrone resistance in PA/C592S·C603S·C608S cells. (b) Topotecan resistance in PA/C592S·C603S·C608S cells. (c) Doxorubicin resistance in PA/C592S·C603S·C608S cells.