Table 3.
Frequencies of inferred haplotypes based on observed genotypes in gastric cancer cases and cancer‐free controls
| EGF haplotypes | Allele frequencies* | OR (95% CI) | |||||
|---|---|---|---|---|---|---|---|
| G61A alleles | G‐1380A alleles | A‐1744G alleles | Cases (n = 1234) | Controls (n = 1320) | |||
| N% | % | N | % | ||||
| G | G | A | 512 | 41.5 | 435 | 32.9 | 1.00 |
| A | G | A | 305 | 24.7 | 386 | 29.3 | 0.67 (0.55–0.82) |
| G | G | G | 218 | 17.7 | 262 | 19.8 | 0.71 (0.57–0.88) |
| G | A | A | 169 | 13.7 | 217 | 16.4 | 0.66 (0.52–0.84) |
| Others † | 30 | 2.4 | 20 | 1.6 | 1.27 (0.71–2.28) | ||
*
P < 0.001 for haplotypes distribution among cases and controls.
†
Including AGG, GAG and AAA haplotyope (haplotype frequencies < 0.05). CI, confidence interval; EGF, epidermal growth factor gene; OR, odds ratio.