Table 4.
Stratified analyses between the combined genotypes of epidermal growth factor promoter polymorphisms and gastric cancer risk
| Variant loci | Cases (n = 617) | Controls (n = 660) | Adjusted OR* (95% CI) | P‐value* | |||
|---|---|---|---|---|---|---|---|
| 0 | ≥1 | 0 | ≥1 | 0 | ≥1 | ||
| n (%) | n (%) | n (%) | n (%) | ||||
| All subjects | 117 (19.0) | 500 (81.0) | 74 (11.2) | 586 (88.8) | 1.00 | 0.53 (0.39–0.73) | <0.001 |
| Age (years) | |||||||
| <60 | 51 (18.8) | 220 (81.2) | 40 (12.9) | 270 (87.1) | 1.00 | 0.63 (0.40–0.99) | 0.050 |
| ≥60 | 66 (19.1) | 280 (80.9) | 34 (9.7) | 316 (90.3) | 1.00 | 0.45 (0.29–0.70) | <0.001 |
| Sex | |||||||
| Male | 76 (17.9) | 348 (82.1) | 53 (12.1) | 387 (88.0) | 1.00 | 0.61 (0.42–0.90) | 0.012 |
| Female | 41 (21.2) | 152 (78.8) | 21 (9.6) | 199 (90.5) | 1.00 | 0.40 (0.22–0.70) | 0.002 |
| Tobacco use | |||||||
| Never | 71 (18.9) | 305 (81.1) | 43 (10.6) | 361 (89.4) | 1.00 | 0.50 (0.33–0.75) | 0.001 |
| Tobacco user | 46 (19.1) | 195 (80.9) | 31 (12.1) | 225 (87.9) | 1.00 | 0.58 (0.35–0.96) | 0.032 |
| Alcohol use | |||||||
| Never | 78 (19.0) | 333 (81.0) | 42 (10.4) | 363 (89.6) | 1.00 | 0.49 (0.33–0.73) | 0.001 |
| Alcohol user | 39 (18.9) | 167 (81.1) | 32 (12.6) | 223 (87.5) | 1.00 | 0.60 (0.35–1.01) | 0.053 |
| H. pylori † | |||||||
| Negative | 26 (17.3) | 124 (82.7) | 31 (12.4) | 219 (87.6) | 1.00 | 0.69 (0.39–1.24) | 0.212 † |
| Positive | 32 (18.8) | 138 (81.2) | 43 (11.0) | 348 (89.0) | 1.00 | 0.51 (0.31–0.85) | 0.010 † |
*
Adjusted for age, sex, smoking and drinking status.
†
320 gastric cancer cases and 641 controls were detected for Helicobacter pylori infection. CI, confidence interval; OR, odds ratio.