Table 6.
Serum pharmacokinetic parameters of total calicheamicin
| Dose (Once/4 weeks) | Treatment Day (n) | Number of cycles | Cmax (ng/mL) (%) | t1/2 (h) (%) | AUC (ng h/mL) (%) | CL (L/h) (%) | Vss (L) (%) |
|---|---|---|---|---|---|---|---|
| 1.3 mg/m2 | 1 (3) | 1 | 44.6 (17) | 17.0 (39) | 987 (44) | 2.35 (58) | 49.44 (13) |
| 29 (3) | 2 | 52.4 (22) | 150.6 (45) | 5754 (40) | 0.38 (48) | 62.86 (30) | |
| 57 (3) | 3 | 56.6 (26) | 216.3 (55) | 8060 (37) | 0.27 (43) | 60.17 (25) | |
| 1.8 mg/m2 | 1 (10) | 1 | 59.0 (31) | 49.6 (77) | 2329 (51) | 1.61 (54) | 72.3 (28) |
| 29 (8) | 2 | 59.4 (15) | 162.4 (34) | 7100 (48) | 0.54 (62) | 89.18 (41) | |
| 57 (5) | 3 | 78.2 (15) | 172.7 (48) | 9225 (32) | 0.37 (44) | 68.37 (26) |
Data are expressed as mean, and percent coefficient of variance is expressed in parentheses. AUC, total area under the concentration‐time curve; CL, clearance; Cmax, peak concentration; NC, not calculated; t1/2, terminal‐phase elimination half‐life (0.693/λz); Vss, steady‐state volume of distribution.