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Representative proliferative lesions developing after promotion with sulfadimethoxine (SDM) for (a) 10 or (b) 15 weeks in a rat two‐stage thyroid carcinogenesis model. (a) Adenoma with follicular features, showing expansive growth with minor atypia. (b) Carcinoma showing obvious cellular atypia, consisting of follicular and solid growth elements with structural irregularity. Note focal necrosis and fibrosis. Hematoxylin–eosin staining. Scale bars = 50 µm.
